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Last modified: Jan 22, 2003 Printer friendly version : [PDF] [PS] NIR predictions of HPLC measurements Key words:   Randomized Blocks, Paired design Description In a pharmaceutical company the use of NIR (Near Infrared Reflectance) spectroscopy was investigated as an alternative to the more cumbersome (and expensive) HPLC method to determine the content of active substance in tablets. Number of observations: 10 Variable                Description hplc The HPLC measurement nir The NIR predicted value Source Brockhoff and Thierry-Carstensen (2003). Test set validation using simple statistical methods. Submitted to: Journal of Chemometrics. Analysis Depending on the purpose: 1)Linear regression. 2) Randomized block design analysis: ANOVA with random tablet effect and fixed method (NIR/HPLC) effect or equivalently a paired t-test. Optimized for Microsoft Internet Explorer 6.0 for Windows webmaster